Article

CRISPR Interference-Mediated Electrical Rescue of Calmodulinopathy Promotes Functional and Structural Maturation in Human iPSC-Derived Engineered Cardiac Tissues

2026-06-15

Abstract excerpt

<title>Abstract</title> <p>Background Calmodulinopathies, caused by mutations such as D130G-CALM2, produce life-threatening arrhythmias by disrupting calcium-dependent inactivation of cardiac calcium channels, resulting in prolonged and unstable repolarization. Effective correction in structured cardiac tissues using genome editing remains challenging. Objective To test CRISPR interference (CRISPRi)-mediated co...

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Literature Corpus work: d233cfe0-e922-5f85-8fdb-804e9db3a7b1
DOI: 10.21203/rs.3.rs-9261158/v1

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