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A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome

21 Oct 2016

Abstract excerpt

Rationale: Calmodulinopathies comprise a new category of potentially life-threatening genetic arrhythmia syndromes capable of producing severe long-QT syndrome (LQTS) with mutations involving CALM1 , CALM2 , or CALM3 . The underlying basis of this form of LQTS is a disruption of Ca 2+ /calmodulin (CaM)-dependent inactivation of L-type Ca 2+ channels. Objective: To gain insight into the mechanistic underpinnings...

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PMID: 27765793
DOI: 10.1161/circresaha.116.309283

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