Article

Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells

2020-09-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan—increasing clinical case reports have documented that it could induce cardiotoxicity including severe arrhythmias and heart failure. As the mechanism by which melphalan impairs cardiac...

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Literature Corpus work: f51ca883-4b46-53a8-999e-e041dfad8338
DOI: 10.21203/rs.3.rs-45895/v2

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