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Article

Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment.

Blood advances - 26 Jan 2021

Stapley Rachel J, Smith Christopher W, Haining Elizabeth J, Bacon Andrea, Lax Sian, Pisareva Vera P, Pisarev Andrey V, Watson Steve P, Khan Abdullah O, Morgan Neil V

Abstract excerpt

Schlafen 14 (SLFN14) has recently been identified as an endoribonuclease responsible for cleaving RNA to regulate and inhibit protein synthesis. Early studies revealed that members of the SLFN family are capable of altering lineage commitment during T-cell differentiation by using cell-cycle arrest as a means of translational control by RNase activity. SLFN14 has been reported as a novel gene causing an inherited...

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Identifiers

PMID: 33496736
DOI: 10.1182/bloodadvances.2020002404
PMCID: PMC7839357

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