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Article

Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation

20 Apr 2018

Abstract excerpt

Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes within bone marrow and crucial for cessation of bleeding at sites of injury. Inherited thrombocytopenias are a group of disorders characterized by a low platelet count and are frequently associated with excessive bleeding. SLFN14 is one of the most recently discovered genes linked to inherited...

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PMID: 29678925
DOI: 10.1261/rna.066415.118

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