Article

Evaluation of TP53 Expression and Mutations among Hematological Malignancies Patients in Saudi Arabia

2021-09-27

Abstract excerpt

Tumor protein 53 ( TP53 ) is the most frequently mutated gene in human cancer which located on the short arm of chromosome 17. In hematological malignancies, the prevalence of TP53 mutations is low compared to other tumors but associated with a complex karyotype, poor prognosis, and poor response to chemotherapy. However, no data on the prevalence and prognostic value of TP53 mutations and the significance of TP53...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1c935b4-c1e8-5ca3-b4f8-ec3531a7432e
DOI: 10.21203/rs.3.rs-928882/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluation of TP53 Expression and Mutations among Hematological Malignancies Patients in Saudi ArabiaDOI 10.21203/rs.3.rs-928882/v1Read

Recent advances in the understanding of TP53 in haematological malignancies.Semantic proximity Read

TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosisSemantic proximity Read

[Clinical and prognostic values of TP53 mutation in patients with acute myeloid leukemia].Semantic proximity Read

Clinical and Molecular Characterization of p53-Mutated Acute Myeloid LeukemiaSemantic proximity Read

TP53 in AML and MDS: The new (old) kid on the block.Semantic proximity Read

Clinical Significance of TP53, PAX5, and JAK2 gene mutation in Pediatric Acute Lymphoblastic LeukemiaSemantic proximity Read

Clinical Significance of TP53, PAX5, and JAK2 gene mutation in Pediatric Acute Lymphoblastic LeukemiaSemantic proximity Read

Clinical implications of subclonal TP53 mutations in acute myeloid leukemiaSemantic proximity Read

TP53 mutations in myeloid neoplasms: implications for accurate laboratory detection, diagnosis, and treatment.Semantic proximity Read

Clinical Characteristics and Outcomes of Pediatric B-Cell Acute Lymphoblastic Leukemia Harboring TP53 Mutations: A Single-Center Retrospective Study.Semantic proximity Read

TP53 in adult acute lymphoblastic leukemia.Semantic proximity Read

[Clinical and prognostic values of TP53 mutation in patients with B-lineage acute lymphoblastic leukemia].Semantic proximity Read