TP53 mutations in myeloid neoplasms: implications for accurate laboratory detection, diagnosis, and treatment.

Abstract excerpt

Genetic alterations that affect the function of p53 tumor suppressor have been extensively investigated in myeloid neoplasms, revealing their significant impact on disease progression, treatment response, and patient outcomes. The identification and characterization of TP53 mutations play pivotal roles in subclassifying myeloid neoplasms and guiding treatment decisions. Starting with the presentation of a typical...

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• Mutation
• Tumor Suppressor Protein p53