Article

VX-809/661 Correction of F508del-CFTR Rescue Nrf2 Dysfunction In CF Airway Epithelia: Supplemental Figures

2019-01-23

Abstract excerpt

Cystic Fibrosis (CF) is a multi-organ progressive genetic disease caused by loss of functional cystic fibrosis transmembrane conductance regulator (CFTR) channel, including in airway epithelia. Previously, we identified a significant dysfunction in CF cells of the transcription factor nuclear-factor-E2-related factor-2 (Nrf2), a major regulator of redox balance and inflammatory signaling. Here we report the discov...

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Literature Corpus work: d1b8ace0-65f6-569b-8231-aada30de9ff4
DOI: 10.1101/529073

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