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Article

Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2).

The Journal of biological chemistry - 15 Jun 2012

Li Wen, Liu Hui, Zhou Jie-Sen, Cao Jiao-Fei, Zhou Xiao-Bo, Choi Augustine M K, Chen Zhi-Hua, Shen Hua-Hao

Abstract excerpt

The Nrf2 (nuclear erythroid 2 p45-related factor-2) signaling pathway is known to play a pivotal role in a variety of oxidative stress-related human disorders. It has been reported recently that the plasma membrane resident protein caveolin-1 (Cav-1) can regulate expression of certain antioxidant enzymes and involves in the pathogenesis of oxidative lung injury, but the detailed molecular mechanisms remain...

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Identifiers

PMID: 22547061
DOI: 10.1074/jbc.M112.352336
PMCID: PMC3375516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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