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Article

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding.

PLoS pathogens - 1 Jul 2022

Bate Neil, Savva Christos G, Moody Peter C E, Brown Edward A, Evans Sian E, Ball Jonathan K, Schwabe John W R, Sale Julian E, Brindle Nicholas P J

Abstract excerpt

Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in development of broad-acting therapeutics and vaccines, and prioritising viral monitoring and containment. Here we use in vitro evolution to seek mutations in SARS-CoV-2...

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Identifiers

PMID: 35849637
DOI: 10.1371/journal.ppat.1010733
PMCID: PMC9333441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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