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Functional cure of hepatitis B requires silencing covalently closed circular and integrated hepatitis B virus DNA

14 Sept 2022

Abstract excerpt

Chronic hepatitis B virus (HBV) infection remains a major global health problem. Hepatitis B surface antigen (HBsAg) loss has been accepted as the definition of a functional HBV cure. Recent studies found that while covalently closed circular DNA (cccDNA) is the predominant source of HBsAg in hepatitis B e antigen-positive (HBeAg-positive) patients, integrated HBV DNA (iDNA) is the main source in HBeAg-negative...

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PMID: 36106633
DOI: 10.1172/jci163175

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