Mendelianization: Concentrating Polygenic Signal into a Single Causal Locus

Abstract excerpt

Complex disorders such as depression and alcohol use involve numerous genetic variants, and implicated loci continue to grow with sample size. This proliferation hampers interpretability, as the mechanisms by which so many variants jointly contribute to pathophysiology remain unclear. In contrast, classical Mendelian diseases arise from a single causal locus and are easier to interpret. We thus introduce Mendelia...

Topics

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• Algorithms
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Models, Genetic
• Multifactorial Inheritance
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

d16d8a6e-8cd9-5c91-8e29-694212b4efd3

DOI

10.1101/2025.10.31.25339237