Article

Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles

2025-02-08

Abstract excerpt

During pregnancy, the maternal immune system adapts to balance tolerance of the semi-allogenic fetus while protecting the fetus from pathogens. Dysregulated immune activity at the maternal-fetal interface contributes to pregnancy complications, such as recurrent pregnancy loss and preeclampsia. Compared to healthy placentas, preeclamptic placentas exhibit increased pro-inflammatory signaling, including a predomina...

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Literature Corpus work: d168ef5f-8a46-5cc0-b0e2-4d2cdf40a59b
DOI: 10.1101/2025.02.07.637086

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