Article
The human placenta shapes the phenotype of decidual macrophages.
Cell reports - 31 Jan 2023
Vondra Sigrid, Höbler Anna-Lena, Lackner Andreas Ian, Raffetseder Johanna, Mihalic Zala Nikita, Vogel Andrea, Saleh Leila, Kunihs Victoria, Haslinger Peter, Wahrmann Markus, Husslein Heinrich, Oberle Raimund, Kargl Julia, Haider Sandra, Latos Paulina, Schabbauer Gernot, Knöfler Martin, Ernerudh Jan, Pollheimer Jürgen
Abstract excerpt
During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. By defining a specific gating strategy, we report the accumulation of macrophages in decB. We describe a decidua basalis-associated macrophage (decBAM) population...
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