Article
MicroRNA miR-27a as a possible regulator of anti-inflammatory macrophage phenotype in preeclamptic placenta.
Placenta - 1 Jan 2024
Vishnyakova Polina, Gantsova Elena, Kiseleva Viktoriia, Lazarev Dmitry, Knyazev Evgeny, Poltavets Anastasiya, Iskusnykh Marina, Muminova Kamilla, Potapova Alena, Khodzhaeva Zulfiya, Elchaninov Andrey, Fatkhudinov Timur, Sukhikh Gennady
Abstract excerpt
INTRODUCTION: The role of the TGFβ signaling pathway, an important cascade responsible for the anti-inflammatory polarization of macrophages, in the development of both early- and late-onset preeclampsia (eoPE and loPE), remains poorly understood. In this study, we examined the components of the TGFβ signaling cascade and macrophage markers within placental tissue in normal pregnancy and in PE. METHODS: Patients...
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