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Placental macrophages present distinct polarization pattern and effector functions depending on clinical onset of preeclampsia

12 Jan 2023

Abstract excerpt

Hofbauer cells (HBCs) are resident macrophages of the human placenta, regulating immune tolerance and tissue homeostasis. HBCs of a normal placenta (CTR) exhibit mainly an anti-inflammatory M2 phenotype. Under exaggerated chronic inflammation during pregnancy, as in preeclampsia (PE), a phenotypic switch towards M1 polarization has been proposed. PE, defined as maternally derived syndrome can be distinguished...

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Birth, Development, and Health
Pregnancy and preeclampsia studies
Reproductive System and Pregnancy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36713449
DOI: 10.3389/fimmu.2022.1095879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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