Article

Cytokine mRNA Delivery and Local Immunomodulation in the Placenta Using Lipid Nanoparticles

2025-07-16

Abstract excerpt

Abstract During pregnancy, the maternal immune system adapts to balance tolerance of the semi‐allogenic fetus while protecting the fetus from pathogens. Dysregulated immune activity at the maternal–fetal interface contributes to pregnancy complications, such as recurrent pregnancy loss and preeclampsia. Compared to healthy placentas, preeclamptic placentas exhibit increased pro‐inflammatory signaling, including a...

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Literature Corpus work: c2b08ba8-5c33-50ca-8816-041e858bf99a
DOI: 10.1002/adtp.202500148

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