Article

Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization

2018-07-09

Abstract excerpt

<h4>ABSTRACT</h4> The p53 tumor suppressor protein, a key regulator of cell apoptosis, has been described to accumulate in affected brain areas from Alzheimer’s disease (AD) patients. However, whether p53 plays any role in AD pathogenesis remains unknown. Here, we found that exposure of neurons to oligomers of the amyloidogenic fragment 25-35 of the Aß peptide (Aβ 25-35 ) activated Cdk5, which promoted p53 prote...

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Literature Corpus work: d1671b8e-d5ea-5991-8972-3054f46d71b5
DOI: 10.1101/365437

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