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CDK5 activator protein p25 preferentially binds and activates GSK3β

20 Oct 2014

Abstract excerpt

Glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5) are tau kinases and have been proposed to contribute to the pathogenesis of Alzheimer's disease. The 3D structures of these kinases are remarkably similar, which led us to hypothesize that both might be capable of binding cyclin proteins--the activating cofactors of all CDKs. CDK5 is normally activated by the cyclin-like proteins p35 and...

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PMID: 25331900
DOI: 10.1073/pnas.1402627111

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