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Article

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 18 Apr 2023

Pao Ping-Chieh, Seo Jinsoo, Lee Audrey, Kritskiy Oleg, Patnaik Debasis, Penney Jay, Raju Ravikiran M, Geigenmuller Ute, Silva M Catarina, Lucente Diane E, Gusella James F, Dickerson Bradford C, Loon Anjanet, Yu Margaret X, Bula Michael, Yu Melody, Haggarty Stephen J, Tsai Li-Huei

Abstract excerpt

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged Cdk5 activation and altered substrate specificity. Elevated p25 levels have been reported in humans and rodents with neurodegeneration, and the benefit of...

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PMID: 37043533
DOI: 10.1073/pnas.2217864120
PMCID: PMC10120002

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