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Article

Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2003

Patzke Holger, Maddineni Upendra, Ayala Ramses, Morabito Maria, Volker Janet, Dikkes Pieter, Ahlijanian Michael K, Tsai Li-Huei

Abstract excerpt

Cyclin-dependent kinase 5 (Cdk5) is activated on binding of activator proteins p35 and p39. A N-terminally truncated p35, termed p25, is generated through cleavage by the Ca(2+)-dependent protease calpain after induction of ischemia in rat brain. p25 has been shown to accumulate in brains of patients with Alzheimer's disease and may contribute to A-beta peptide-mediated toxicity. Studies from transfected neurons...

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PMID: 12684463
PMCID: PMC6742110

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Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.PMID 12684463Read ↗

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