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AβPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576

1 Nov 2002

Abstract excerpt

Previous studies of Abeta-induced neuronal damage of hippocampal cells in culture have provided strong evidence that deregulation of the Cdk5/p35 kinase system is involved in the neurodegeneration pathway. Cdk5 inhibitors and antisense probes neuroprotected hippocampal cells against the neurotoxic action of Abeta. To further investigate the mechanisms underlying the participation of Cdk5 in neuronal degeneration,...

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PMID: 12446973
DOI: 10.3233/jad-2002-4508

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