Article

Gene editing of pigs to control influenza A virus infections

2024-01-16

Abstract excerpt

Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA which is cleaved by ubiquitous proteases, such as furin; in contrast, the monobasic HA motif is recognized and activated by trypsin-like proteases, such as the transmembrane serine protea...

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Literature Corpus work: d161df7e-9f0b-536d-a424-cca40367d7cd
DOI: 10.1101/2024.01.15.575771

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