Article

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical use

2022-06-09

Abstract excerpt

African Swine Fever (ASF) is a viral disease with exceptionally high lethality in domestic pigs and wild boar worldwide 1, 2 , without any effective vaccine or drug to prevent its spread. In this study, we established a multiplexable CRISPR-Cas-gRNA system targeting 13 genomic loci in the ASF virus genome that could prevent viral replication by cutting its genome. Furthermore, we generated pig strains expressing...

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Literature Corpus work: 98abccf1-37c4-5c80-8d06-b2915cb5c701
DOI: 10.1101/2022.06.09.495443

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