Article

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical use

2022-07-18

Abstract excerpt

African Swine Fever (ASF) is a viral disease with exceptionally high lethality in domestic pigs and wild boar worldwide, without any effective vaccine or drug to prevent its spread. In this study, we established a multiplexable CRISPR-Cas-gRNA system targeting 13 genomic loci in the ASF virus genome that could prevent viral replication by cutting its genome. Furthermore, we generated pig strains expressing the mul...

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Literature Corpus work: e28b514e-2dbb-5aa1-83d3-83bf30e2668a
DOI: 10.21203/rs.3.rs-1741328/v1

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