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Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virus

2 Apr 2024

Abstract excerpt

ABSTRACT African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and infection. By engineering CRISPR-Cas systems to target nine specific loci within the ASFV genome, we observed a substantial reduction in viral replication...

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PMID: 38563791
DOI: 10.1128/spectrum.02164-23

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