Article
Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies.
Oncotarget - 28 Jun 2016
Carter Corey A, Zeman Karen, Day Regina M, Richard Patrick, Oronsky Arnold, Oronsky Neil, Lybeck Michelle, Scicinski Jan, Oronsky Bryan
Abstract excerpt
Like Chinese boxes nesting inside each other, the classification of non-small cell lung cancer (NSCLC) is subdivided into smaller and smaller subtypes on the basis of histological and molecular attributes. The latter characterizes NSCLC by its molecular alterations and the identification of inhibitors that target these cancer-specific "driver" mutations. Despite the initial promise of precision-guided therapies...
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