Article

Enhanced Renal Fibrosis Therapy via Smad3 Silencing using Low- Molecular-Weight Chitosan-Modified PLA Nanoparticles

2026-05-20

Abstract excerpt

<title>Abstract</title> <p>Renal fibrosis represents the final common pathway of chronic kidney disease, driven largely by TGF-β/Smad3 signaling. While silencing Smad3 offers therapeutic potential, the clinical application of small interfering RNA (siRNA) is hindered by rapid degradation and poor cellular uptake. To overcome these barriers, we developed a polylactic acid (PLA) nanoparticle system surface-modified...

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Literature Corpus work: d1494d40-7cf4-5e95-a8e4-c02dab125e03
DOI: 10.21203/rs.3.rs-9522463/v1

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