Article

Targeted glomerular mesangium transfection by antifibrotic gene nanocarriers inhibits kidney fibrosis and promotes regeneration

2024-03-04

Abstract excerpt

<title>Abstract</title> <p>Renal fibrosis and loss of kidney function are key characteristics of chronic kidney disease (CKD). To address the lack of effective treatments, multifunctional layer-by-layer (LbL) assembled polymeric gene-carrier nanoparticles (PCHS-NP) are prepared to realize preferential accumulation and retention within the renal mesangium, thereby effectively leveraging cortically localized struct...

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Literature Corpus work: ed2bfb67-1fc8-5ab5-a33e-647f44abedd1
DOI: 10.21203/rs.3.rs-4003494/v1

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