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CRISPR/Cas9-Mediated Cldn2 Knockout in HCT116 Cells, Reveals Its Crucial Role in Colorectal Cancer progression

2025-03-01

Abstract excerpt

<h4>Background</h4> Colon cancer progression heavily relies on intricate mechanisms of invasion, metastasis, and migration. Tight junction protein Cldn2 has emerged as a potential regulator of these processes. This study aimed to elucidate the molecular mechanisms linking Clan2 deletion to gene expression changes related to motility, invasion, and metastasis in colon caner. <h4>Methods</h4> CRISPR/Cas9-mediated...

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Literature Corpus work
7afe4c7e-5517-5f30-9b93-6e2ddf140100
DOI
10.1101/2025.02.28.640859
Open publication

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CRISPR/Cas9-Mediated Cldn2 Knockout in HCT116 Cells, Reveals Its Crucial Role in Colorectal Cancer progressionDOI 10.1101/2025.02.28.640859
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