Translocation mechanism of xeroderma pigmentosum group D protein on single-stranded DNA and genetic disease etiology.

doi:10.1038/s41467-025-66834-1

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Article

Translocation mechanism of xeroderma pigmentosum group D protein on single-stranded DNA and genetic disease etiology.

Nature communications - 28 Nov 2025

Paul Tanmoy, Yan Chunli, Derdeyn-Blackwell Grant, Ivanov Ivaylo

Abstract excerpt

XPD is a key nucleotide excision repair (NER) protein whose function is vital for genome integrity. During NER, XPD serves as a 5'-3' single-strand DNA translocase that enables lesion scanning and verification in genomic DNA. Yet, its translocation mechanism is incompletely understood. Here we use molecular simulations and chain-of-replicas path optimization methods to model the ATP-driven translocation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41315283
DOI: 10.1038/s41467-025-66834-1
PMCID: PMC12753804

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