Article

Adaptive Immunity Governs Regional Aortic Remodeling in Hypertension via Perivascular Adipose Tissue Plasticity

2025-07-27

Abstract excerpt

Hypertension drives heterogeneous aortic remodeling, but the mechanisms underlying regional disparities remain unclear. Here, we demonstrate that adaptive immunity orchestrates spatial differences in vascular dysfunction by modulating perivascular adipose tissue (PVAT) phenotype and immune-metabolic crosstalk. Using angiotensin II (AngII)-infused wild-type (WT) and Rag1 −/− mice lacking T and B cells, we integra...

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Literature Corpus work: d123e100-7d4e-5759-bd33-f114fdbc3be3
DOI: 10.1101/2025.07.23.666477

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