Article

A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissue

2025-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Perivascular adipose tissue (PVAT), an intriguing layer of fat surrounding blood vessels, regulates vascular tone and mediates vascular dysfunction through mechanisms that are not well understood. Here we show with single nucleus RNA-sequencing of thoracic aortic PVAT from Dahl SS rats that a high-fat (HF) hypertensive diet induces coordinated changes in gene expression across the diverse cell t...

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Literature Corpus work: 4787a874-d384-5bdb-bc69-c19eae848380
DOI: 10.1101/2025.02.13.636878

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