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<i>Candida albicans</i> reprograms host inosine metabolism to drive immunosuppressive macrophage polarization and gastric cancer carcinogenesis

2026-05-30

Abstract excerpt

Gastric cancer (GC) is strongly associated with changes in the gastric microbiome. However, the direct contribution of individual pathogenic species to tumor initiation and progression remains poorly defined. Here, we identified Candida albicans ( C. albicans ), a fungus that ranks as the most significantly enriched taxon in GC tissues, can directly promote gastric carcinogenesis. We found that when C . albica...

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Literature Corpus work
b3059003-289e-53f3-851d-75d96324e9b9
DOI
10.64898/2026.05.27.728170
Open publication

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