Article

Leveraging epigenetic signatures to determine the cell-type of origin from long read sequencing data

2024-06-03

Abstract excerpt

DNA methylation differs across tissue- and cell-types with important implications for the analysis of disease-associated differences in tissues such as blood. To uncover the biological processes affected by epigenetic dysregulation, it is essential for epigenetic studies to generate data from the appropriate cell-types. Here we propose a framework to do this computationally from long-read sequencing data, bypassin...

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Literature Corpus work: d0fb256a-4a0b-5e04-882f-ca3e41178a02
DOI: 10.1101/2024.06.03.597114

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