Article

A Plasticity Framework for Hoarding Disorder: Cross-Disorder Genomic Comparisons Reveal Divergent Compulsivity Mechanisms

2026-01-06

Abstract excerpt

<h4>Background: </h4> Hoarding disorder (HD) has been classed alongside obsessive-compulsive disorder (OCD) for decades, yet its later age of onset, ego-syntonic saving, and limited response to OCD treatments imply a separate biology. <h4>Methods:</h4> We re-analysed the 2022 genome-wide association meta-analysis of hoarding symptoms with the same three-step pipeline recently applied on a larger 2025 OCD GWAS. The...

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Literature Corpus work: d0c9f701-7f5b-5788-b22d-e2d8a62fc98e
DOI: 10.20944/preprints202601.0274.v1

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