Article

Time-dependent epigenomic changes during 3D spheroid culture improve the preclinical modeling of non-small cell lung cancer

2025-11-19

Abstract excerpt

<title>Abstract</title> <p> Background The chance of surviving non-small cell lung cancer (NSCLC) is low, due to the challenge in replicating it in preclinical models, limiting the discovery of effective treatments. Most preclinical models rely on two-dimensional (2D) cancer cell cultures. However, they do not reflect the effects of the 3D tumor architecture on cell proliferation, gene expression, and epigenomic...

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Literature Corpus work: f7b5ffa3-eb79-5474-b532-6837a1ade8e6
DOI: 10.21203/rs.3.rs-8000509/v1

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