Article

Human forebrain assembloids modeling a neurodevelopmental disorder reveals neural circuit deficits via DNA damage

2025-11-14

Abstract excerpt

<title>Abstract</title> <p>Cortical circuit dysfunction is strongly linked to neurodevelopmental disorders (NDDs). The mechanisms by which disruptions in early cortical development lead to defects in mature human neural circuit function are not well understood. Here, using human forebrain assembloids from individuals with the 15q13.3 microdeletion syndrome, we identified dysregulation of early gene networks in co...

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Literature Corpus work: d0a96724-0c24-5d5f-bb04-8daa0422fd6d
DOI: 10.21203/rs.3.rs-7957934/v1

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