Article

CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis of lung cancer cells via PERK-ATF4 and IRE1α-JNK pathway

2023-05-16

Abstract excerpt

<title>Abstract</title> <p>Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R3 expression is downregulated in human lung cancer cell lines and tissues. Adenoviral overexpression of CYB5R3 suppresses lung cancer cell growth <i...

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Literature Corpus work: d087f5e4-cd45-53a2-b417-59fd374f8ca8
DOI: 10.21203/rs.3.rs-2810245/v1

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