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Article

BNIP3 in Lung Cancer: To Kill or Rescue?

16 Nov 2020

Abstract excerpt

Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most...

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PMID: 33207677
DOI: 10.3390/cancers12113390

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