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Article

The Hippo Pathway as a Driver of Select Human Cancers.

Trends in cancer - 1 Sept 2020

Kulkarni Aishwarya, Chang Matthew T, Vissers Joseph H A, Dey Anwesha, Harvey Kieran F

Abstract excerpt

The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Although Hippo has been linked to multiple aspects of cancer, its role in this disease is incompletely understood. Large-scale pan-cancer analyses of core Hippo pathway genes reveal that the pathway is mutated at a high frequency only in select human cancers, including malignant mesothelioma...

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Identifiers

PMID: 32446746
DOI: 10.1016/j.trecan.2020.04.004

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