Article
Functional annotation of the Hippo pathway somatic mutations in human cancers.
Nature communications - 21 Nov 2024
Han Han, Huang Zhen, Xu Congsheng, Seo Gayoung, An Jeongmin, Yang Bing, Liu Yuhan, Lan Tian, Yan Jiachen, Ren Shanshan, Xu Yue, Xiao Di, Yan Jonathan K, Ahn Claire, Fishman Dmitry A, Meng Zhipeng, Guan Kun-Liang, Qi Ruxi, Luo Ray, Wang Wenqi
Abstract excerpt
The Hippo pathway is commonly altered in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development remains unclear. Here we analyze the Hippo somatic mutations in the human cancer genome and functionally annotate their roles in targeting the Hippo pathway. We identify a total of 85 loss-of-function (LOF) missense mutations for Hippo pathway genes...
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