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Article

Long-range effects of a peripheral mutation on the enzymatic activity of cytochrome P450 1A2.

Journal of chemical information and modeling - 27 Jun 2011

Zhang Tao, Liu Limin Angela, Lewis David F V, Wei Dong-Qing

Abstract excerpt

The human cytochrome P450 1A2 is an important drug metabolizing and procarcinogen activating enzyme. An experimental study found that a peripheral mutation, F186L, at ∼26 Å away from the enzyme's active site, caused a significant reduction in the enzymatic activity of 1A2 deethylation reactions. In this paper, we explored the effects of this mutation by carrying out molecular dynamics simulations and structural...

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PMID: 21598960
DOI: 10.1021/ci200112b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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