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Article

Insight into the structural and functional analysis of the impact of missense mutation on cytochrome P450 oxidoreductase.

Journal of molecular graphics & modelling - 1 Nov 2020

Kumar Rajalakshmi, Jayaraman Manikandan, Ramadas Krishna, Chandrasekaran Adithan

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) is a steroidogenic and drug-metabolizing enzyme. It helps in the NADPH dependent transfer of electrons to cytochrome P450 (CYP) enzymes for their biological activity. In this study, we employed integrative computational approaches to decipher the impact of proline to leucine missense mutation at position 384 (P384L) in the connecting/hinge domain region which is essential for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32805558
DOI: 10.1016/j.jmgm.2020.107708

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