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Epigenetics in prostate cancer: clinical implications

15 Jun 2021

Abstract excerpt

Epigenetic alterations, including changes in DNA methylation, histone modifications and nucleosome remodeling, result in abnormal gene expression patterns that contribute to prostate tumor initiation and continue to evolve during the course of disease progression. Epigenetic modifications are responsible for silencing tumor-suppressor genes, activating oncogenic drivers, and driving therapy resistance and thus...

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PMID: 34430414
DOI: 10.21037/tau-20-1339

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