Article

Characterization of Novel Human β-glucocerebrosidase Antibodies for Parkinson Disease Research

2023-09-15

Abstract excerpt

<h4>BACKGROUND</h4> Mutations in GBA1 , which encodes the lysosome enzyme β-glucocerebrosidase (also referred to as acid β-glucosidase or GCase), are the most common genetic risk factor for Parkinson disease (PD) and dementia with Lewy bodies (DLB). Evidence also suggests that loss of GCase activity is implicated in PD without GBA1 mutations. Consequently, therapies targeting GCase are actively being pursued as...

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Literature Corpus work: d06ff42a-957c-553c-948b-eb5c8d7a722b
DOI: 10.1101/2023.09.14.557851

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