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Article

Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease.

Journal of molecular biology - 15 Jun 2023

Chatterjee Diptaman, Krainc Dimitri

Abstract excerpt

Beta-glucocerebrosidase is a lysosomal hydrolase, encoded by GBA1 that represents the most common risk gene associated with Parkinson's disease (PD) and Lewy Body Dementia. Glucocerebrosidase dysfunction has been also observed in the absence of GBA1 mutations across different genetic and sporadic forms of PD and related disorders, suggesting a broader role of glucocerebrosidase in neurodegeneration. In this...

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Identifiers

PMID: 36828270
DOI: 10.1016/j.jmb.2023.168023
PMCID: PMC10247409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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