Article

Systems Level Identification of a Matrisome-Associated Macrophage Polarization State in Multi-Organ Fibrosis

2022-12-20

Abstract excerpt

Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages which respond to an initial inflammatory insult common in all forms of fibrosis. The recently unraveled multi-organ heterogeneity of macrophages in healthy and fibrotic human disease suggest that tissue resident macrophages, expressing osteopontin (SPP1), associate with lung and liver fibrosis. However, the conservation of...

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Literature Corpus work: d06e5693-4a8f-5112-9bdf-e6f6815af9a6
DOI: 10.1101/2022.12.20.521178

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