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SPP1 macrophages across diseases: A call for reclassification?

6 Mar 2025

Abstract excerpt

SPP1+ macrophages, characterized by elevated expression of the osteopontin gene (secreted phosphoprotein 1, SPP1), have emerged as key players in various pathological contexts, including aging, chronic inflammatory diseases, and cancer. While frequently classified as a subclass of tumor-associated macrophages in oncological settings, their presence in noncancer conditions, such as aging-related disorders and...

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PMID: 40047497
DOI: 10.1096/fj.202403227r

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