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CD163+ macrophages drive rapid pulmonary fibrosis via osteopontin secretion

3 Jun 2025

Abstract excerpt

Background Rapid pulmonary fibrosis (RPF) is a severe condition characterized by the rapid accumulation of excessive extracellular matrix (ECM), resulting in high mortality among patients with severe respiratory infections. CD163 + macrophages were found to be enriched in RPF patients, their role in this disease requires elucidation. Methods We integrated single-cell RNA sequencing (scRNA-seq) and single-nucleus...

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PMID: 40466617
DOI: 10.1016/j.intimp.2025.114976

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